A long list of disorders is associated with aberrant angiogenesis or chronic inflammation states, which are caused by a dysregulated activity of the uPA/uPAR system (Mahmood et al., 2018; Cammalleri et al., 2019; D’Alonzo etal., 2020).
Common Diseases:
Diabetic Nephropathy
Diabetic Retinopathy
Inflammatory Bowel Disease
Acute Kidney Disease
Acute Respiratory Distress Syndrome
Age-related macular degeneration
Cancer
Rare Diseases:
Retinitis Pigmentosa
Cystic Fibrosis
Retinopathy of the Prematurity
Hereditary Angioedema
Hereditary Hemorrhagic Telangiectasia
Rubeosis Iridis
Neovascular glaucoma
For many of these disorders, no adequate therapeutic strategies are available or they involve expensive, invasive treatments, often requiring surgery and prolonged hospitalization.
No cure is available
Standard of care: intravitreal drug injection
No specific cure is available for DN
Some compounds have been found to interfere with the uPA/uPAR system and have been proposed for the treatment of some important pathologies (D’Alonzo et al., 2020). Unfortunately, none of them has yet found a valid application as drug.
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