Medical Needs

A long list of disorders is associated with aberrant angiogenesis or chronic inflammation states, which are caused by a dysregulated activity of the uPA/uPAR system (Mahmood et al., 2018; Cammalleri et al., 2019; D’Alonzo etal., 2020).

Common Diseases:
Diabetic Nephropathy
Diabetic Retinopathy
Inflammatory Bowel Disease
Acute Kidney Disease
Acute Respiratory Distress Syndrome
Age-related macular degeneration

Rare Diseases:
Retinitis Pigmentosa
Cystic Fibrosis
Retinopathy of the Prematurity
Hereditary Angioedema
Hereditary Hemorrhagic Telangiectasia
Rubeosis Iridis
Neovascular glaucoma

For many of these disorders, no adequate therapeutic strategies are available or they involve expensive, invasive treatments, often requiring surgery and prolonged hospitalization.

Retinitis Pigmentosa is a rare genetic disorder (1/4000) involving progressive degeneration of photoreceptor rods in the retina

No cure is available
Diabetic Retinopathy is a complication of diabetes, caused by high blood sugar levels damaging the retina

Standard of care: intravitreal drug injection
Diabetic Nephropathy is a kidney disease caused by diabetes, involving chronic loss of kidney function due to severe proteinuria

No specific cure is available for DN

Some compounds have been found to interfere with the uPA/uPAR system and have been proposed for the treatment of some important pathologies (D’Alonzo et al., 2020). Unfortunately, none of them has yet found a valid application as drug.

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